Immune tolerance is defined as the failure of a host to mount an immune response to a specific antigen. Pharmacologic induction of immune tolerance is intended to prevent the immune response to an alloantigen (e.g. a transplanted organ) or to a self-antigen (e.g. diabetes mellitus, Crohn's disease, arthritis), without the need for long-term immunosuppressive therapy. Navigating the complex network of molecular interactions that mediate immune tolerance is challenging. Ongoing studies continue to add data to the complex knowledge base of immune tolerance mechanisms.
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