Zoltan Szallasi MD

     Children's Hospital Informatics Program
Harvard Medical School

zszallasi@chip.org
phone: 617-355-2179
Welcome back to my website on genetic network analysis.
First, I would like to apologize to all of those who tried to visit my old (and now defunct) website at my former university, USUHS. That webpage on genetic network analysis was prematurely removed for reasons not quite clear to me.

I am sorry for the inconvenience. In the meanwhile you can download the latest tutorial handout, as presented at the 2nd International Conference on Systems Biology (Caltech, November 2001)

You can find here a set of Commentaries I have written for the journal "Trends in Pharmacological Sciences". These commentaries cover a wide range of topics from the human genome project to prion detection. The real fun in writing commentaries is that one express ideas and views that have not been elevated to the level of "scientific truth" (yet).
 
 

Publications:

1.Szallasi, Z. Gene expression patterns and cancer. Nature Biotech.  16:1292-  1293, 1998.

2.Szallasi, Z. and Liang, S.  Modeling the Normal and Neoplastic Cell Cycle With "Realistic BooleanGenetic Networks": Their Application for
Understanding Carcinogenesisand Assessing Therapeutic Strategies.   Pacific Symp. on Biocomputing 3:66-76 1998.

3. Ribar, B., Grallert, A, Olah, E and Szallasi, Z. Deletion of the sep1+ forkhead transcription factor homologue is not lethal but causes hyphal growth in Schizosaccharomyces pombe   Biochim. Biophys. Res. Comm.  263:465-474, 1999.

4. Szallasi, Z. Genetic network analysis in light of massively parallel biological data acquisition. Pacific Symp. on Biocomputing.  4:5-16,  1999

5. Klus, G.T., Song, A., Schick, A., Wahde, M. and Szallasi, Z. Mutual information  analysis as a tool to assess the role of aneuploidy in the generation of cancer-associated differential gene expression patterns. Pacific Symp. on Biocomputing. , 6:42-51, 2001.

6. Wahde, M. and Szallasi Z.  Generative model based analysis of cancer associated gene expression matrices. Proceedings of the First International Conference on Systems Biology:39-45.  2001.

7. Klus, G.T., Rokaeus N., Bittner M.L., Chen Y., Korz D.M., Sukumar S., Schick A., and Szallasi Z. Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. Int.J. Oncol. 19:169-174,  2001

8. Wahde, M., Klus, G., Bittner, M., Chen, Y and Szallasi, Z. Assessing the significance of consistently mis-regulated genes in cancer associated gene expression matrices. Bioinformatics. 18:389-394,  2002.