Intelligent Health Lab

 
 
 
Kenneth D. Mandl, MD, MPH
 

Associate Professor, Harvard Medical School

Faculty, Children's Hospital Informatics Program at the Harvard-MIT Division of Heatlh Sciences and Technology

Co-Director, PHIConnect, a CDC Center of Excellence in Public Heatlh Informatics

Affiliated Faculty, Harvard-MIT Division of Health, Sciences & Technology

Faculty, MIT Center for Biomedical Informatics

Faculty, Division of Emergency Medicine, Children's Hospital Boston

 
     
 
EDUCATION
 
 

1998-9 Medical Informatics Coursework, Massachusetts Institute of Technology
1995 MPH, Clinical Effectiveness, Harvard School of Public Heatlh
1989 MD, Harvard Medical School
1985 AB, Biology and Psychology, Brown University

 
     
 
RESEARCH
 
 

Public Health Informatics
Biosurveillance
Detection of emerging infections, epidemics, outbreaks, attacks
Decision support and clinican reporting tools for real time surveillance

Personally Controlled Health Records
The IndivoHealth project

  • personally controlled, web-based, ubiquitous medical records
  • a National Library of Medicine funded, health applications for the Next Generation Internet project
 
     
 
AWARDS
 
  Presidential Early Career Award for Scientists and Engineers (PECASE) , the White House, 2005
2004 Investing in Information Award, Massachusetts Heatlh Data Consortium
 
     
  PROFESSIONAL SOCIETIES  
  American Society for Clinical Investigation (elected)  
  American Pediatric Society (elected)  
  Society for Pediatric Research (elected)  
  American Medical Informatics Association  
     
SELECTED PUBLICATIONS
 

Wieland SC, Brownstein JS, Berger B, Mandl KD. Density-equalizing Euclidean minimum spanning trees for the detection of all disease cluster shapes. Proc Natl Acad Sci U S A 2007  [In Press]

McMurry AJ, Gilbert CA, Reis BY, Chueh HC, Kohane IS, Mandl KD.  A self-scaling, distributed architecture for public health, research, and clinical care. J Am Med Inform Assoc. July 2007 [In Press]

Reis BY, Kohane IS, Mandl KD. An epidemiological network model for disease outbreak detection. PLoS Medicine 2007 [In Press]

Wieland SC, Brownstein JS, Berger B, Mandl KD. Automated real time constant-specificity surveillance for outbreaks. BMC Med Inform Decis Mak [In Press]

Kohane IS, Mandl KD, Taylor PL, Holm IA, Nigrin DJ, Kunkel LM. MEDICINE: Reestablishing the Researcher-Patient Compact. Science. May 11, 2007 2007;316(5826):836-837.

Fine AM, Goldmann DA, Forbes PW, Harris SK, Mandl KD. Incorporating Vaccine-Preventable Disease Surveillance Into the National Health Information Network: Leveraging Children's Hospitals. Pediatrics 2006;118(4):1431-8.

Brownstein JS, Cassa CA, Kohane IS, Mandl KD. An unsupervised classification method for inferring original case locations from low-resolution disease maps. Int J Health Geogr. 2006;5:56.

Fine AM, Nigrovic LE, Reis BY, Cook EF, Mandl KD. Linking Surveillance to Action: Incorporation of Real-time Regional Data into a Medical Decision Rule. J Am Med Inform Assoc. March 1, 2007 2007;14(2):206-211.

Brownstein JS, Wolfe CJ, Mandl KD. Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Medicine. 2006;3(10):e401.

Olson KL, Grannis SJ, Mandl KD. Privacy protection versus cluster detection in spatial epidemiology. Am J Public Health. Nov 2006;96(11):2002-2008.

Bourgeois FT, Valim C, Wei JC, McAdam AJ, Mandl KD. Influenza and Other Respiratory Virus-Related Emergency Department Visits Among Young Children. Pediatrics 2006;118(1):e1-8.

Kimia A, Brownstein JS, Olson KL, Zak V, Bourgeois FT, Mandl KD. Lumbar Puncture Ordering and Results in the Pediatric Population: A Promising Data Source for Surveillance Systems. Acad Emerg Med.2006;13(7):767-773.

Mohtashemi, M, Szolovits P, Dunyak J. Mandl KD. A susceptible-infected model of early detection of respiratory infection outbreaks on a background of influenza. Journal of Theoretical Biology. 2006; 241: 954–963.

Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med. May 8 2006;25(11):1823-1825.

Bourgeois FT, Olson KL, Brownstein JS, McAdam AJ, Mandl KD. Validation of syndromic surveillance for respiratory infections. Ann Emerg Med. Mar 2006;47(3):265 e261.

Cassa CA, Grannis SJ, Overhage JM, Mandl KD. A context-sensitive approach to anonymizing spatial surveillance data: impact on outbreak detection. J Am Med Inform Assoc 2006;13(2):160-5.

Brownstein JS, Kleinman KP, Mandl KD. Identifying Pediatric Age Groups for Influenza Vaccination Using a Real-Time Regional Surveillance System. Am. J. Epidemiol. October 1, 2005 2005;162(7):686-693.

Cassa CA, Iancu K, Olson KL, Mandl KD. A software tool for creating simulated outbreaks to benchmark surveillance systems. BMC Med Inform Decis Mak. Jul 14 2005;5(1):22-28.

Olson KL, Bonetti M, Pagano M, Mandl KD. Real time spatial cluster detection using interpoint distances among precise patient locations. BMC Med Inform Decis Mak. Jun 21 2005;5(1):19-30.

Ma H, Rolka H, Mandl KD, Buckeridge DL, Pavlin JA, Fleischauer AT, Endy T. Lab order data implementation in the BioSense early outbreak detection system. MMWR Morb Mortal Wkly Rep.Aug 26 2005;54(SU-1):27-30.

Daniel JB, Heisey-Grove D, Gadam P, Yih WK, Mandl KD, DeMaria A, Platt R. Connecting health departments and providers: syndromic surveillance's last mile. MMWR Morb Mortal Wkly Rep. Aug 26 2005;54 Suppl:147-150.

Kleinman KP, Abrams AM, Mandl KD, Platt R. Simulation for assessing statistical methods of bioterrorism surveillance. MMWR Morb Mortal Wkly Rep.Aug 26 2005;54(SU-1):101-108.

Wang L, Ramoni M, Mandl KD, Sebastiani P. Factors Affecting Syndromic Surveillance. Artificial Intelligence in Medicine. Artif Intell Med. Jul 2005;34(3):269-278.

Mandl KD, Reis BY, Cassa C. Measuring outbreak detection performance using controlled feature set simulations. MMWR Morb Mortal Wkly Rep. Sep 24 2004;53 Suppl:130-136.2004;53

Reis BY, Mandl KD. Syndromic surveillance: the effects of syndrome grouping on model accuracy and outbreak detection. Ann Emerg Med. Sep 2004;44(3):235-241.  

Fine AM, Wong JB, Fraser HS, Fleisher GR, Mandl KD. Is it influenza or anthrax? A decision analytic approach to the treatment of patients with influenza-like illnesses. Ann Emerg Med. Mar 2004;43(3):318-328.  

Chung S, Mandl KD, Shannon M, Fleisher GR. Efficacy of an Educational Web Site for Educating Physicians about Bioterrorism. Acad Emerg Med. Feb 2004;11(2):143-148. 

Mandl KD, Overhage JM, Wagner MM, Lober WB, Sebastiani P, Mostashari F, Pavlin J, Gesteland PH, Treadwell T, Koski E, Hutwagner L, Buckeridge DL, Aller R, Grannis S. Syndromic surveillance: a guide informed by the early experience.  J Am Med Inform Assoc. Mar-Apr 2004; 11(2): 141-150. PrePrint published Nov 21, 2003  

Beitel AJ, Olson KL, Reis BY, Mandl KD. Use of emergency department chief complaint and diagnostic codes for identifying respiratory illness in a pediatric population. Pediatr Emerg Care. Jun 2004;20(6):355-360.  

Bonetti M, Olson K, Mandl K, Pagano M. Parametric models for interpoint distances and their use in biosurveillance. Proceedings of the American Statistical Association, Biometrics Section [CDROM] 2003  

Reis BY, Mandl KD. Integrating syndromic surveillance data across multiple locations: effects on outbreak detection performance. Proc AMIA Symp. 2003; 549-53.    

Reis BY, Pagano M, Mandl KD. Using temporal context to improve biosurveillance. Proc Natl Acad Sci U S A. 2003;100(4):1961-1965. 

Reis BY, Mandl KD. Time series modeling for syndromic surveillance. BMC Med Inform Decis Mak. 2003;3(1):http://www.biomedcentral.com/1472-6947/1473/1472. 

Sebastiani P, Mandl KD. Biosurveillance and outbreak detection using syndromic data. Data Mining:  Next Generation Challenges and Future Directions. Cambridge, MA: AAAI/MIT Press; 2003 (In Press). 

Lober WB, Karras BT, Wagner MM, Overhage JM, Davidson AJ,  Fraser H,  Trigg LJ, Mandl KD, Espino JU, Tsui FC.  Roundtable on bioterrorism detection: information systems -based surveillance.  Journal of the American Medical Informatics Association 2002; 9(2) 105-115. 

Mandl KD. Infrastructure and methods to support real time biosurveillance.  Proceedings of the National Science Foundation Next Generation Data Mining Workshop.  2002. http://www.cs.umbc.edu/ngdm02. 

Shannon M, Burstein J, Mandl KD, Fleisher GR.  Usage of a web-based decision support tool for bioterrorism detection. American Journal of Emergency Medicine. Am J Emerg Med 2002; 20: 384-385  

Personally controlled health records


Simons WW, Mandl KD, Kohane IS. The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc. Jan-Feb 2005;12(1):47-54.

Sax U, Kohane I, Mandl KD. Wireless Technology Infrastructures for Authentication of Patients: PKI that Rings. J Am Med Inform Assoc 2005;12(3):263-8.

Porter SC, Kohane IS, Goldmann DA. Parents as partners in obtaining the medication history. J Am Med Inform Assoc 2005;12(3):299-305.

Mandl KD, Szolovits P, Kohane IS. Public standards and patients' control: how to keep electronic medical records accessible but private. BMJ. 2001;322(7281):283-287. 

Porter SC, Fleisher GR, Kohane IS, Mandl KD. The Value of Parental Report for Diagnosis and Management of Dehydration in the Emergency Department. Ann Emerg Med 2003;41:196-205.  

Riva A, Mandl KD, Oh DH, et al. The personal internetworked notary and guardian. Int J Med Inf. 2001;62(1):27-40. 

Digital divide

Mandl KD, Feit S, Pena BM, Kohane IS. Growth and determinants of access in patient e-mail and Internet use. Arch Pediatr Adolesc Med. May 2000;154(5):508-511.   

Mandl KD, Katz SB, Kohane IS. Social equity and access to the World Wide Web and E-mail: implications for design and implementation of medical applications. Proc AMIA Symp. 1998:215-219.

Protected health information

Mandl KD, Feit S, Larson C, Kohane IS. Newborn screening program practices in the United States: notification, research, and consent. Pediatrics. Feb 2002;109(2):269-273.

Medical communication

Mandl KD, Kohane IS. Healthconnect: clinical grade patient-physician communication. Proc AMIA Symp. 1999:849-853.   

Mandl KD, Kohane IS, Brandt AM. Electronic patient-physician communication: problems and promise. Ann Intern Med. 1998;129(6):495-500.

Training

Mandl KD, Lee TH. Integrating medical informatics and health services research: the need for dual training at the clinical health systems and policy levels. J Am Med Inform Assoc. Mar-Apr 2002;9(2):127-132.

Non-Medical
May Contain Nuts A Very Loose Canon of American Humor. Ed. Michael J. Rosen. 2004: Harper Collins.

Read about Ken Mandl in Sanghavi, D. A Map of the Child: A Pediatrician's Tour of the Body. Owl Books 2004.