Biosurveillance and real time population health monitoring
Personally controlled health records
Digital divide
Distributed information systems
Clinical decision support
Protected health information
Medical communication
Training
Biosurveillance and real time population health monitoring
Brownstein JS, Sordo M, Kohane IS, Mandl KD. The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. PLoS ONE. 2007;2(9):e840-.
Reis BY, Kirby C, Hadden LE, et al. AEGIS: A Robust and Scalable Real-time Public Health Surveillance System. J Am Med Inform Assoc. September-October 2007;14(5):581-588.
Bourgeois FT, Porter SC, Valim C, Jackson T, Cook EF, Mandl KD. The Value of Patient Self-Report for Disease Surveillance. J Am Med Inform Assoc. Aug 21 2007.
Wieland SC, Brownstein JS, Berger B, Mandl KD. Density-equalizing Euclidean minimum spanning trees for the detection of all disease cluster shapes. PNAS. May 22, 2007 2007:0609457104.
Wieland SC, Brownstein JS, Berger B, Mandl KD. Automated real time constant-specificity surveillance for disease outbreaks. BMC Medical Informatics and Decision Making. 2007;7(1):15-.
Reis BY, Kohane IS, Mandl KD. An epidemiological network model for disease outbreak detection. PLoS Medicine. June 01, 2007 2007;4(6):e210.
McMurry AJ, Gilbert CA, Reis BY, Chueh HC, Kohane IS, Mandl KD. A Self-scaling, Distributed Information Architecture for Public Health, Research, and Clinical Care. J Am Med Inform Assoc. July 1, 2007 2007;14(4):527-533.
Fine AM, Goldmann DA, Forbes PW, Harris SK, Mandl KD. Incorporating Vaccine-Preventable Disease Surveillance Into the National Health Information Network: Leveraging Children's Hospitals. Pediatrics 2006;118(4):1431-8.
Brownstein JS, Cassa CA, Kohane IS, Mandl KD. An unsupervised classification method for inferring original case locations from low-resolution disease maps. Int J Health Geogr. 2006;5:56.
Fine AM, Nigrovic LE, Reis BY, Cook EF, Mandl KD. Linking Surveillance to Action: Incorporation of Real-time Regional Data into a Medical Decision Rule. J Am Med Inform Assoc. March 1, 2007 2007;14(2):206-211.
Brownstein JS, Wolfe CJ, Mandl KD. Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Medicine. 2006;3(10):e401.
Olson KL, Grannis SJ, Mandl KD. Privacy protection versus cluster detection in spatial epidemiology. Am J Public Health. Nov 2006;96(11):2002-2008.
Bourgeois FT, Valim C, Wei JC, McAdam AJ, Mandl KD. Influenza and Other Respiratory Virus-Related Emergency Department Visits Among Young Children. Pediatrics 2006;118(1):e1-8.
Kimia A, Brownstein JS, Olson KL, Zak V, Bourgeois FT, Mandl KD. Lumbar Puncture Ordering and Results in the Pediatric Population: A Promising Data Source for Surveillance Systems. Acad Emerg Med.2006;13(7):767-773.
Mohtashemi, M, Szolovits P, Dunyak J. Mandl KD. A susceptible-infected model of early detection of respiratory infection outbreaks on a background of influenza. Journal of Theoretical Biology. 2006; 241: 954–963.
Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med. May 8 2006;25(11):1823-1825.
Bourgeois FT, Olson KL, Brownstein JS, McAdam AJ, Mandl KD. Validation of syndromic surveillance for respiratory infections. Ann Emerg Med. Mar 2006;47(3):265 e261.
Cassa CA, Grannis SJ, Overhage JM, Mandl KD. A context-sensitive approach to anonymizing spatial surveillance data: impact on outbreak detection. J Am Med Inform Assoc 2006;13(2):160-5.
Brownstein JS, Kleinman KP, Mandl KD. Identifying Pediatric Age Groups for Influenza Vaccination Using a Real-Time Regional Surveillance System. Am. J. Epidemiol. October 1, 2005 2005;162(7):686-693.
Cassa CA, Iancu K, Olson KL, Mandl KD. A software tool for creating simulated outbreaks to benchmark surveillance systems. BMC Med Inform Decis Mak. Jul 14 2005;5(1):22-28.
Olson KL, Bonetti M, Pagano M, Mandl KD. Real time spatial cluster detection using interpoint distances among precise patient locations. BMC Med Inform Decis Mak. Jun 21 2005;5(1):19-30.
Ma H, Rolka H, Mandl KD, Buckeridge DL, Pavlin JA, Fleischauer
AT, Endy T. Lab order data implementation in the BioSense early
outbreak detection system. MMWR Morb Mortal Wkly Rep.Aug 26 2005;54(SU-1):27-30.
Daniel JB, Heisey-Grove D, Gadam P, Yih WK, Mandl KD, DeMaria
A, Platt R. Connecting health departments and providers: syndromic
surveillance's last mile.
MMWR Morb Mortal Wkly Rep. Aug 26 2005;54 Suppl:147-150.
Kleinman KP, Abrams AM, Mandl KD, Platt R. Simulation for assessing
statistical methods of bioterrorism surveillance. MMWR Morb Mortal Wkly Rep.Aug 26 2005;54(SU-1):101-108.
Wang L, Ramoni M, Mandl KD, Sebastiani P. Factors
Affecting Syndromic Surveillance. Artificial Intelligence in
Medicine. Artif Intell Med. Jul 2005;34(3):269-278.
Mandl KD, Reis BY, Cassa C. Measuring outbreak detection performance
using controlled feature set simulations. MMWR Morb Mortal Wkly Rep. Sep 24 2004;53 Suppl:130-136.2004;53
Reis BY, Mandl KD. Syndromic surveillance: the effects of syndrome
grouping on model accuracy and outbreak detection. Ann Emerg Med.
Sep 2004;44(3):235-241.
Fine AM, Wong JB, Fraser HS, Fleisher GR, Mandl KD. Is it influenza
or anthrax? A decision analytic approach to the treatment of patients
with influenza-like illnesses. Ann Emerg Med. Mar 2004;43(3):318-328.
Brownstein JS, Holford TR, Fish D. Enhancing West Nile virus surveillance,
United States. Emerg Infect Dis. Jun 2004;10(6):1129-1133.
Chung S, Mandl KD, Shannon M, Fleisher GR. Efficacy of an Educational
Web Site for Educating Physicians about Bioterrorism. Acad Emerg
Med. Feb 2004;11(2):143-148.
Mandl KD, Overhage JM, Wagner MM, Lober WB, Sebastiani
P, Mostashari F, Pavlin J, Gesteland PH, Treadwell T, Koski E, Hutwagner
L, Buckeridge DL, Aller R, Grannis S. Syndromic surveillance: a
guide informed by the early experience.
J
Am Med Inform Assoc. Mar-Apr 2004; 11(2):
141-150. PrePrint published Nov 21, 2003
Beitel AJ, Olson KL, Reis BY, Mandl KD. Use of emergency department
chief complaint and diagnostic codes for identifying respiratory
illness in a pediatric population. Pediatr Emerg Care. Jun 2004;20(6):355-360.
Bonetti M, Olson K, Mandl K, Pagano M. Parametric
models for interpoint distances and their use in biosurveillance.
Proceedings of the American Statistical Association, Biometrics
Section [CDROM] 2003
Reis BY, Mandl KD. Integrating syndromic surveillance
data across multiple locations: effects on outbreak detection performance.
Proc
AMIA Symp. 2003; 549-53.
Reis BY, Pagano M, Mandl KD. Using temporal context
to improve biosurveillance. Proc
Natl Acad Sci U S A. 2003;100(4):1961-1965.
Reis BY, Mandl KD. Time series modeling for syndromic
surveillance. BMC
Med Inform Decis Mak. 2003;3(1):http://www.biomedcentral.com/1472-6947/1473/1472.
Sebastiani P, Mandl KD. Biosurveillance and outbreak
detection using syndromic data. Data Mining: Next Generation Challenges
and Future Directions. Cambridge, MA: AAAI/MIT Press; 2003 (In Press).
Lober WB, Karras BT, Wagner MM, Overhage JM, Davidson
AJ, Fraser H, Trigg LJ, Mandl KD, Espino JU, Tsui FC. Roundtable
on bioterrorism detection: information systems -based surveillance.
Journal
of the American Medical Informatics Association 2002; 9(2) 105-115.
Mandl KD. Infrastructure and methods to support
real time biosurveillance. Proceedings of the National Science
Foundation Next Generation Data Mining Workshop. 2002. http://www.cs.umbc.edu/ngdm02.
Shannon M, Burstein J, Mandl KD, Fleisher GR.
Usage of a web-based decision support tool for bioterrorism detection.
American Journal of Emergency Medicine. Am J Emerg Med 2002; 20:
384-385
Kohane IS. The contributions of biomedical informatics
to the fight against bioterrorism. J Am Med Inform Assoc. Mar-Apr
2002;9(2):116-119.
Henretig FM, Cieslak TJ, Kortepeter MG, Fleisher
GR. Medical management of the suspected victim of bioterrorism:
an algorithmic approach to the undifferentiated patient. Emerg
Med Clin N Am 2002; 20: 351-364.
Shannon M. Bioterrorism and Pediatrics: A Perspective.
Ped Alert 2001; 26: 121-122
Personally controlled health records
Kohane IS, Mandl KD, Taylor PL, Holm IA, Nigrin DJ, Kunkel LM. MEDICINE: Reestablishing the Researcher-Patient Compact. Science. May 11, 2007 2007;316(5826):836-837.
Adida B, Kohane IS. GenePING: secure, scalable management of personal genomic data. BMC Genomics 2006;7(1):93.
Kohane IS, Altman RB. Health-information altruists--a potentially critical resource. N Engl J Med 2005;353(19):2074-7.
Simons WW, Mandl KD, Kohane IS. The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc. Jan-Feb 2005;12(1):47-54.
Sax U, Kohane I, Mandl KD. Wireless Technology Infrastructures for Authentication of Patients: PKI that Rings. J Am Med Inform Assoc 2005;12(3):263-8.
Porter SC, Cai Z, Gribbons W, Goldmann DA, Kohane IS. The asthma kiosk: a patient-centered technology for collaborative decision support in the emergency department. J Am Med Inform Assoc 2004;11(6):458-67.
Porter SC, Kohane IS, Goldmann DA. Parents as partners in obtaining the medication history. J Am Med Inform Assoc 2005;12(3):299-305.
Mandl KD, Szolovits P, Kohane IS. Public standards
and patients' control: how to keep electronic medical records
accessible but private. BMJ. 2001;322(7281):283-287.
Porter SC, Fleisher GR, Kohane IS, Mandl KD. The Value of Parental
Report for Diagnosis and Management of Dehydration in the Emergency
Department. Ann Emerg Med 2003;41:196-205.
Riva A, Mandl KD, Oh DH, et al. The personal
internetworked notary and guardian. Int
J Med Inf. 2001;62(1):27-40.
Porter SC, Kohane IS. Optimal data entry by patients: effects
of interface structure and design. Medinfo. 2001;10(Pt 1):141-145.
Nigrin DJ, Kohane IS. Glucoweb: a case study of secure, remote
biomonitoring and communication. Proc AMIA Symp. 2000:610-614.
Digital divide
Mandl KD, Feit S, Pena BM, Kohane IS. Growth and
determinants of access in patient e-mail and Internet use. Arch
Pediatr Adolesc Med. May 2000;154(5):508-511.
Mandl KD, Katz SB, Kohane IS. Social equity and access to the World
Wide Web and E-mail: implications for design and implementation
of medical applications. Proc AMIA Symp. 1998:215-219.
Distributed information systems
Namini AH, Berkowicz DA, Kohane IS, Chueh H. A submission model
for use in the indexing, searching, and retrieval of distributed
pathology case and tissue specimens. Medinfo. 2004;2004:1264-1267.
Nigrin DJ, Kohane IS. Scaling a data retrieval and mining application
to the enterprise-wide level. Proc AMIA Symp. 1999:901-905.
Wang K, van Wingerde FJ, Bradshaw K, Szolovits P, Kohane I. A Java-based
multi-institutional medical information retrieval system. Proc AMIA
Annu Fall Symp. 1997:538-542.
Wang K, Kohane I, Bradshaw KL, Fackler J. A real time patient monitoring
system on the World Wide Web. Proc AMIA Annu Fall Symp. 1996:729-732.
van Wingerde FJ, Schindler J, Kilbridge P, et al. Using HL7 and
the World Wide Web for unifying patient data from remote databases.
Proc AMIA Annu Fall Symp. 1996:643-647.
Kohane IS, van Wingerde FJ, Fackler JC, et al. Sharing electronic
medical records across multiple heterogeneous and competing institutions.
Proc AMIA Annu Fall Symp. 1996:608-612.
Clinical decision support
Cai Z, Tsung EF, Marinescu VD, Ramoni MF, Riva A, Kohane IS. Bayesian
approach to discovering pathogenic SNPs in conserved protein domains.
Hum Mutat. Aug 2004;24(2):178-184.
Sun Y, van Wingerde FJ, Kohane IS, et al. The challenges of automating
a real-time clinical practice guideline. Clin Perform Qual Health
Care. Jan-Mar 1999;7(1):28-35.
Nigrin DJ, Kohane IS. Data mining by clinicians. Proc AMIA Symp.
1998:957-961.
Protected health information
Mandl KD, Feit S, Larson C, Kohane IS. Newborn screening program
practices in the United States: notification, research, and consent.
Pediatrics. Feb 2002;109(2):269-273.
Kohane IS, Dong H, Szolovits P. Health information identification
and de-identification toolkit. Proc AMIA Symp. 1998:356-360.
Rind DM, Kohane IS, Szolovits P, Safran C, Chueh HC, Barnett GO.
Maintaining the confidentiality of medical records shared over the
Internet and the World Wide Web. Ann Intern Med. Jul 15 1997;127(2):138-141.
Medical communication
Mandl KD, Kohane IS. Healthconnect: clinical grade
patient-physician communication. Proc
AMIA Symp. 1999:849-853.
Mandl KD, Kohane IS, Brandt AM. Electronic patient-physician communication:
problems and promise. Ann
Intern Med. 1998;129(6):495-500.
Training
Mandl KD, Lee TH. Integrating medical informatics and health services
research: the need for dual training at the clinical health systems
and policy levels. J
Am Med Inform Assoc. Mar-Apr 2002;9(2):127-132.
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