Publications by CHIP Investigators

We include here some electronic reprints (or pointers to) publications by CHIP investigators that may be of most general interest.

Bioinformatics	Clinical Informatics
Pharmacogenomic investigation of carcinogenesis. Butte AJ, Tamayo P, Slonim D, Golub TR, Kohane IS. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks [In Process Citation]. Proc Natl Acad Sci U S A 2000;97(22):12182-6.	An early proposal for cryptographic health identifiers Szolovits P, Kohane I. Against simple universal health identifiers. Journal of the American Medical Informatics Association 1994;1(4):316-319. and mechanism to implement flexible identification systems Kohane IS, Dong H, Szolovits P. Health Information Identification and De-Identification Toolkit. In: Chute C, editor. Proceedings, Annual Fall Symposium of the American Medical Informatics Association; 1998; Florida: Hanley and Belfus, Inc; 1998. p. 356-360.
A novel algorithm for optimal partitioning of classes of genes. Kim JH, Ohno-Machado L, Kohane IS. Unsupervised learning from complex data: the Matrix Incision Tree Algorithm. In: Pacific Symposium on Biocomputing; 2001; Hawaii; 2001. p. 30-41.	A mechanism for distributed peer review meeting the needs of several user communities. Kohane IS, Altman RB. The new peer review. Proc AMIA Symp 2000;(20(Suppl)):433-7.
Looking for regulatory networks in yeast expression data sets. Butte A, Kohane I. Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements. In: Altman R, Dunker K, Hunter L, Lauderdale K, Klein T, editors. Pacific Symposium on Biocomputing 2000; 2000; Hawaii: World Scientific; 2000. p. 418-429.	The common research agenda in bioinformatics and clinical informatics. Kohane IS. Bioinformatics and clinical informatics: the imperative to collaborate. J Am Med Inform Assoc 2000;7(5):512-6.
Addressing the poor reproducibility of fold differences. A. J. Butte, J.Ye, G. Niederfellner, K. Rett, Häring HU, M.F.White, et al. Determining significant fold differences in gene expression analysis. In: Altman R, editor. Pacific Symposium on Biocomputing; 2001; Hawaii; 2001. p. 6-17.	The means for achieving nation-wide electronic medical records. Kohane IS, Greenspun P, Fackler J, Cimino C, Szolovits P. Building National Electronic Medical Record Systems via the World Wide Web. Journal of the American Medical Informatics Association 1996;3(3):191-207.
Creating customizable masks to screen out irreproducible genes in expression microarray experiments. Tsien CL, Libermann TA, Gu X, Kohane IS. On Reporting Fold Differences. In: Pacific Symposium on Biocomputing; 2001; Hawaii; 2001. p. 496-507.	Early results documenting the digital divide and its relevance to healthcare delivery. Mandl KD, Feit S, Pena B, Kohane I. Growth and determinants of access in patient e-mail and Internet use. Arch Pediatr Adolesc Med 2000;154(5):508-511.
Introduction to the insights provided by a dynamics perspective on expression data sets. Reis BY, Atul S. Butte, Kohane IS. Extracting Knowledge from Dynamics in Gene Expression. Journal of Biomedical Informatics 2001;1(1):1-13.