2001 : January - June.
The CHIP journal club meets each Monday, from 11:00 AM - 12:00 PM, in the Carnegie classroom at Boston Children's Hospital. Papers are generally available by Friday of the week prior to the talk for review. They may be be picked up at Dr. Isaac Kohane's office. Each weekly conference is approved for 1 credit of AMA Category 1 Continuing Medical Education credit.

If you would like to sign-up for a date or have any questions, please contact jc-contact@www.chip.org

January 1^st, New Year's Day

January 8^th, Cancelled due to Pacific Symposium on Biocomputing 2001

January 15^th, Martin Luther King Jr.'s Day

January 22^nd, Marco Ramoni, Ph.D.

• "The Statistical Insignificance of Fold Changes in the Analysis of Genome-wide Expression Data"

January 29^th, Vikki Marinescu, M.S. & Steve Greenberg, M.D.

• Paper review:  "RNA expression analysis analysis using a 30 base pair resolution Escherichia coli genome array (Selinger et al., Nature Biotechnology 18, 2000)"

February 5^th, DSG: Nelson Hsing, Ph.D.

• Cost-effectiveness Study of Protective Precaution for Acute Leukemia Patients.

February 12^nd, CHIP: Kayla Cytryn, RN, M.Sc., Ph.D.

• Reasoning about Health, Illness, and Disease: Implications for the Use of Technology (see Patel et al, JAMIA 2000;7:569-585.)

February 19^th, President's Day

February 26^th, DSG: William Salomon, M.D. [meet in Seminar 2 Conference Room]

• Implementation of Clinical Guidelines via a Computer Charting System (Schriger et al. JAMIA 2000;7:186-195) [powerpoint slides]

March 5^th, Cancelled due to Snow. Originally scheduled talk by Dr. Alberto Riva moved to April 2nd.

March 12^th, DSG: John Nadai, M.D.

• Informatics Approaches to Home Health Care.
• Home telehealthcare is the provision of various interventions in patients’ homes using computing and communications technology, usually, but not exclusively, for monitoring and management of chronic illness.  Studies have shown its ability to improve medical care and cost-effectiveness.
• The talk will review one or two papers detailing studies of various applications of the field, e.g. hypertension, medication compliance, heart failure, and asthma.

March 19^th, CHIP: Douglas Selinger, Ph.D. (Cand.) [meet in Byers Conference Room A, Lobby Level, Enders Building]

• "RNA expression analysis analysis using a 30 base pair resolution Escherichia coli genome array (Selinger et al., Nature Biotechnology 18, 2000)"

March 26^th, DSG: Jeeyae Choi, Ph.D.

• Comprehending Object and Process Models: An Empirical Study. (Agarwal, P. De, and A. Sinha)

April 2^nd, CHIP: Alberto Riva, Ph.D.

• A Review of SNPs.
• Brookes AJ, The essence of SNPs, Gene 234 (1999) 177-186.
• Schork NJ et al, Single Nucleotide Polymorphisms and the Future of Genetic Epidemiology, Clin Genet 58 (2000) 250-264
• Johnson GCL and Todd JA, Strategies in Complex Disease Mapping, Current Opinions in Genetics and Development 10 (2000) 330-334

April 9^th, Passover

April 16^th, Patriot's Day

April 23^rd, CHIP: Isaac Kohane, M.D., Ph.D.

• Case study of a time-series analysis: "The Core Meiotic Transcriptome in Budding Yeast" (Michael Primig, et al. Nature, December 2000, Vol 26, p 415)

April 30^th, DSG: William Saloman, M.D.

• From Paper to Practice: Challenges in Implementing Guidelines (powerpoint slides)

May 7^th, CHIP: Hamish Fraser, M.D., M.S.

• Informatic Support for the Management of Drug-Resistant Tuberculosis in Peru and Russia
• Tuberculosis remains one of the leading causes of death world wide despite the availability of effective antimicrobial therapy. Recently multi-drug resistant tuberculosis (MDR-TB) has become an important problem. Innovative treatment strategies have been developed to treat MDR-TB but while effective they require more complex drug regimens and more expertise than normal TB management. We have developed informatics tools to support programs in Peru and Russia. The core of the system, a database-backed Web site, stores data about patients' clinical status, current and previous medication, drug sensitivity testing results. Digital images of radiographs can be entered with a custom telemedicine application and viewed with a Web based viewer. Another component monitors medication requirements and creates reports on required supplies. The design philosophy and implementation of these systems is described here.

May 14^th, DSG: Agnieszka Szet

• Review of "Multicentre randomised control trial comparing real time teledermatology with conventional outpatient dermatological care: societal cost-benefit analysis." (Wootton R et al, BMJ 320:1252-1256 (2000), link)

May 21^st, CHIP: Marco Ramoni, Ph.D.

• Temporal Profiling of Gene Expression Data using Bayesian Clustering by Dynamics.

May 28^th, Memorial Day

June 4^th, DSG: Eun-Younng Kim, M.D.

• Immunofluorescence Histogram Analysis
• Proof without prejudice revisited: Immunofluorescence histogram analysis using cumulative frequency subtraction plus ratio analysis of means. Cytometry. 2001 Jan 1;43(1):55-68.
• Evaluation of the number of positive cells from flow cytometric immunoassays by mathematical modeling of cellular autofluorescence. Cytometry. 1994 Apr 1;15(4):294-301
• Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources. J Histochem Cytochem. 1977 Jul;25(7):935-41

June 11^th, CHIP: Stephano Monti, Ph.D., research scientist at Whitehead Institute.

• Analysis of gene expression data for tumor classification and outcome prediction

June 18^th, DSG:

June 25^th, CHIP: Yao Sun, M.D.

• <TBA>

Last updated: April 4, 2001.                                                Questions? Comments?  Send mail to Eric Pan.