An area of CHIP pioneering innovation is federated networks, a practice which enables decentralized approaches to data distributed across sites. From our faculty’s earliest forays into the field with the Shared Pathology Information Network (The NCI funded “Napster for pathology samples”) to the first demonstration of federated research networks for biosurveillance, to development of the Shared Health Research Innovation Network (SHRINE) network.

Our program has worked with sister academic medical institutions to establish globally scalable technology, policies and procedures for sharing genomic, phenotypic and biospecimen data on broadly consented cohorts, across sites of care. We have, in partnership with our sister sites, developed two federated data sharing commons, the Genomic Research and Innovation Network (GRIN) and the Genomic Information Commons (GIC). Our faculty have developed the first query portal in the world that provides a uniform interface that enables users to retrieve genomic data, phenotypic data and biospecimen metadata in a single query. The technology, policies, and procedures that we have developed enable us to acquire additional partners and scale our federated data sharing globally.

Projects

Publications

Geisler BP, Zahabi L, Lang AE, Eastwood N, Tennant E, Lukic L, Sharon E, Chuang HH, Kang CB, Clayton-Johnson K, Aljaberi A, Yu H, Bui C, Le Mau T, Li WC, Teodorescu D, Hinske LC, Sun DL, Manian FA, Dunn AG. Repurposing existing medications for coronavirus disease 2019: protocol for a rapid and living systematic review. Systematic reviews 2021.

Börcsök J, Diossy M, Sztupinski Z, Prosz A, Tisza V, Spisak S, Rusz O, Stormoen DR, Pappot H, Csabai I, Brunak S, Mouw KW, Szallasi Z. Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 2021.

Geva A, Albert BD, Hamilton S, Manning MJ, Barrett MK, Mirchandani D, Harty M, Morgan EC, Kleinman ME, Mehta NM. eSIMPLER: A Dynamic, Electronic Health Record-Integrated Checklist for Clinical Decision Support During PICU Daily Rounds. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2021.

Li J, Tiwari A, Mirzakhani H, Wang AL, Kho AT, McGeachie MJ, Litonjua AA, Weiss ST, Tantisira KG. Circulating MicroRNA: Incident Asthma Prediction and Vitamin D Effect Modification. Journal of personalized medicine 2021.

Larsen RJ, Gagoski B, Morton SU, Ou Y, Vyas R, Litt J, Grant PE, Sutton BP. Quantification of magnetic resonance spectroscopy data using a combined reference: Application in typically developing infants. NMR in biomedicine 2021.