Natural Language Processing Laboratory

Our mission is to develop and implement Natural Language Processing (NLP) technologies to apply to the electronic medical record.  These technologies include core NLP tasks such as relation extraction, coreference resolution, and parsing, and make use of statistical machine learning methods.  In order to use many machine learning methods, manually labeled (annotated) domain- and task-specific data is required.  To that end, we are heavily involved in many different clinical document annotation projects.  Since manual annotation is a time-consuming, painstaking, expensive process, it is also our goal to develop and use algorithms that minimize the required amount of labeled data required while maximizing the use of existing labeled data.

The Programmatic Outbreak Response and [socio-]Technical Analytics Lab (PORTAL)

PORTAL uses probabilistic modeling, data science, and “systems epidemiology” in the context of public health, with a focus on causal inference to advance infectious disease surveillance using digital disease data (e.g. search trends; news and social media).

The Registry and Informatics R&D (RIR&D) Group

The RIR&D Group is focused on the development and application of innovative, open-source, data-driven solutions to challenges faced by longitudinal disease registries and related studies. A principal focus of our group is informatics-based strategies to enhance the collection and sharing of clinical research data within the 75+ site Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, serving as a paradigm for other similar longitudinal chronic disease registries. Members of the CHIP RIR&D Group include specialists in software architecture and development for multi-site/multi-source regulatory-grade clinical research data warehousing, research data coordination, research analytics and computable phenotyping, and related IRB and regulatory/legal matters for clinical trials.

The Manrai Lab

The Manrai Lab is a team of machine learning scientists, clinicians, and biomedical data scientists working to improve medical decision making by developing computational approaches that incorporate rich and deep representations of clinical state and an individual's identity into care. Active projects include: improving genetic variant classification and quantifying risk ("penetrance") for inherited heart disease, measuring "normal" variation for blood lab biomarkers across populations focused on creatinine and kidney disease, developing semi-supervised learning approaches for multi-modal imaging, and modeling reproducibility in integrative biomedical studies using meta-science ("science of science") approaches.

The Pediatric Therapeutics and Regulatory Science Initiative

The Pediatric Therapeutics and Regulatory Science Initiative provides a forum for collaboration with academia, patients, policymakers, and industry. Its aim is to advance the development and evidence-based use of novel therapeutics for children globally.

Inclusion Body Myositis Research

The Inclusion Body Myositis Research group is dedicated to understanding and finding treatment for sporadic inclusion body myositis (s-IBM), dermatomyositis, polymyositis, and other inflammatory myopathies.

SMART Health IT

SMART Health IT advances medicine, discovery and public health through parsimonious, open standards, application programming interfaces, laws and regulation, and is best known for the SMART on FHIR API. 

Laboratory for Neuroinformatics and Neurodiagnostics (LNN)

The LNN develops computational methods for extracting digital biomarkers for brain disorders from EEG measurements. Our approach to EEG signal analysis is based in complex dynamical systems theory. Entropy measures, recurrence plot and recurrence network analysis, neural synchronization, and tensor data structures all play a role. 

Computational Epidemiology Lab

The Computational Epidemiology Lab conducts a diverse set of projects to predict patterns of disease, analyze patterns of epidemics, use of satellite data and public health surveillance tools. 

Avillach Lab

The Avillach Lab investigates translational bioinformatics, specifically in integrating multiple heterogeneous sources of clinical and genomics data in a meaningful way. 

Translational Omics Medicine Lab

The Translational Omics Medicine Lab develops methods to molecularly characterize patients for research and discovery. 

Machine Intelligence Lab

The Machine Intelligence Lab has a multidisciplinary research agenda. The research involves the conception and implementation of machine intelligence analytics tools, capable of predicting unobserved events in health care in the immediate or near future. 

Predictive Medicine Group

The Predictive Medicine Group works to develop novel approaches for predicting human health. Our diverse group of researchers, clinicians, mathematicians, computer scientists and biologists develop advanced predictive models for a wide range of applicants, including disease risk prediction, predictive pharmacovigilance, predictive health system dynamics and real-time public health surveillance. 

Publications

Kiang MV, Santillana M, Chen JT, Onnela JP, Krieger N, Engø-Monsen K, Ekapirat N, Areechokchai D, Prempree P, Maude RJ, Buckee CO. Incorporating human mobility data improves forecasts of Dengue fever in Thailand. Scientific reports 2021.

Rubinstein YR, Robinson PN, Gahl WA, Avillach P, Baynam G, Cederroth H, Goodwin RM, Groft SC, Hansson MG, Harris NL, Huser V, Mascalzoni D, McMurry JA, Might M, Nellaker C, Mons B, Paltoo DN, Pevsner J, Posada M, Rockett-Frase AP, Roos M, Rubinstein TB, Taruscio D, van Enckevort E, Haendel MA. The case for open science: rare diseases. JAMIA open 2020.

Ferenczi S, Solymosi N, Horváth I, Szeőcs N, Grózer Z, Kuti D, Juhász B, Winkler Z, Pankotai T, Sükösd F, Stágel A, Paholcsek M, Dóra D, Nagy N, Kovács KJ, Zanoni I, Szallasi Z. Efficient treatment of a preclinical inflammatory bowel disease model with engineered bacteria. Molecular therapy. Methods & clinical development 2021.

Liu D, Olson KL, Manzi SF, Mandl KD. Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. Genetics in medicine : official journal of the American College of Medical Genetics 2021.

Diao JA, Inker LA, Levey AS, Tighiouart H, Powe NR, Manrai AK. In Search of a Better Equation - Performance and Equity in Estimates of Kidney Function. The New England journal of medicine 2021.