The Boston Children's Hospital Computational Health Informatics Program (CHIP), founded in 1994, is a multidisciplinary applied research and education program. Our faculty advance the science of biomedical informatics for molecular characterization of the patient, gene discovery, medical decision making, diagnosis, therapeutic selection, care redesign, public health management, population health, and re-imagined clinical trials. Biomedical informatics has become a major theme and methodology for biomedical science, health care delivery, and population health, involving high-dimensional modeling and understanding of patients from the molecular to the population levels. The field is inherently interdisciplinary, drawing on traditional biomedical disciplines, the science and technology of computing, data science, biostatistics, epidemiology, decision theory, omics, implementation science, and health care policy and management. CHIP faculty are trained in medicine, data science, computer science, mathematics and epidemiology. Though CHIP has a robust pediatric research agenda, our contributions span across all ages. CHIP is a collaborating program with the Department of Biomedical Informatics at Harvard Medical School.

The Program’s innovations have transformed the landscape of big data in health care, the use of AI in clinical decision making, and the IT strategies of commercial enterprises. CHIP discoveries and inventions have been widely adopted by technology companies such as: Apple, Microsoft, Google, Facebook, and Amazon.

Leading projects include the SMART on FHIR “app store for health”, the cTAKES pipeline for computerized “reading” of clinical text, the HealthMap global surveillance system, the VaccineFinder tool to help the public locate COVID-19 vaccines, and the federated data sharing Genomic Information Commons.

CHIP software is reading millions of doctors’ notes across sites of care and surfacing key insights about adverse medication effects. CHIP research has strongly influenced public policy from vaccine recommendations to health IT provisions in the 21st Century Cures Act to paradigm shifts in data provisioning by CMS. CHIP’s biosurveillance computational platforms have found the earliest signals of Ebola outbreaks. On the basis of these advances, Health 2.0 voted Boston Children's Hospital the 10 Year Global Retrospective Top Influencer among all health care organizations.

Publications

Diao JA, Powe NR, Manrai AK. Race-Free Equations for eGFR: Comparing Effects on CKD Classification. Journal of the American Society of Nephrology : JASN 2021.

Plana D, Tian E, Cramer AK, Yang H, Carmack MM, Sinha MS, Bourgeois FT, Yu SH, Masse P, Boyer J, Kim M, Mo J, LeBoeuf NR, Li J, Sorger PK. Assessing the filtration efficiency and regulatory status of N95s and nontraditional filtering face-piece respirators available during the COVID-19 pandemic. BMC infectious diseases 2021.

Cromwell EA, Osborne JCP, Unnasch TR, Basáñez MG, Gass KM, Barbre KA, Hill E, Johnson KB, Donkers KM, Shirude S, Schmidt CA, Adekanmbi V, Adetokunboh OO, Afarideh M, Ahmadpour E, Ahmed MB, Akalu TY, Al-Aly Z, Alanezi FM, Alanzi TM, Alipour V, Andrei CL, Ansari F, Ansha MG, Anvari D, Appiah SCY, Arabloo J, Arnold BF, Ausloos M, Ayanore MA, Baig AA, Banach M, Barac A, Bärnighausen TW, Bayati M, Bhattacharyya K, Bhutta ZA, Bibi S, Bijani A, Bohlouli S, Bohluli M, Brady OJ, Bragazzi NL, Butt ZA, Carvalho F, Chatterjee S, Chattu VK, Chattu SK, Cormier NM, Dahlawi SMA, Damiani G, Daoud F, Darwesh AM, Daryani A, Deribe K, Dharmaratne SD, Diaz D, Do HT, El Sayed Zaki M, El Tantawi M, Elemineh DA, Faraj A, Fasihi Harandi M, Fatahi Y, Feigin VL, Fernandes E, Foigt NA, Foroutan M, Franklin RC, Gubari MIM, Guido D, Guo Y, Haj-Mirzaian A, Hamagharib Abdullah K, Hamidi S, Herteliu C, Hidru HD, Higazi TB, Hossain N, Hosseinzadeh M, Househ M, Ilesanmi OS, Ilic MD, Ilic IM, Iqbal U, Irvani SSN, Jha RP, Joukar F, Jozwiak JJ, Kabir Z, Kalankesh LR, Kalhor R, Karami Matin B, Karimi SE, Kasaeian A, Kavetskyy T, Kayode GA, Kazemi Karyani A, Kelbore AG, Keramati M, Khalilov R, Khan EA, Khan MNN, Khatab K, Khater MM, Kianipour N, Kibret KT, Kim YJ, Kosen S, Krohn KJ, Kusuma D, La Vecchia C, Lansingh VC, Lee PH, LeGrand KE, Li S, Longbottom J, Magdy Abd El Razek H, Magdy Abd El Razek M, Maleki A, Mamun AA, Manafi A, Manafi N, Mansournia MA, Martins-Melo FR, Mazidi M, McAlinden C, Meharie BG, Mendoza W, Mengesha EW, Mengistu DT, Mereta ST, Mestrovic T, Miller TR, Miri M, Moghadaszadeh M, Mohammadian-Hafshejani A, Mohammadpourhodki R, Mohammed S, Mohammed S, Moradi M, Moradzadeh R, Moraga P, Mosser JF, Naderi M, Nagarajan AJ, Naik G, Negoi I, Nguyen CT, Nguyen HLT, Nguyen TH, Nikbakhsh R, Oancea B, Olagunju TO, Olagunju AT, Omar Bali A, Onwujekwe OE, Pana A, Pourjafar H, Rahim F, Rahman MHU, Rathi P, Rawaf S, Rawaf DL, Rawassizadeh R, Resnikoff S, Reta MA, Rezapour A, Rubagotti E, Rubino S, Sadeghi E, Saghafipour A, Sajadi SM, Samy AM, Sarmiento-Suárez R, Sawhney M, Schipp MF, Shaheen AA, Shaikh MA, Shamsizadeh M, Sharafi K, Sheikh A, Shetty BSK, Shin JI, Shivakumar KM, Simonetti B, Singh JA, Skiadaresi E, Soheili A, Soltani S, Spurlock EE, Sufiyan MB, Tabuchi T, Tapak L, Thompson RL, Thomson AJ, Traini E, Tran BX, Ullah I, Ullah S, Uneke CJ, Unnikrishnan B, Uthman OA, Vinkeles Melchers NVS, Violante FS, Wolde HF, Wonde TE, Yamada T, Yaya S, Yazdi-Feyzabadi V, Yip P, Yonemoto N, Yousof HSA, Yu C, Yu Y, Yusefzadeh H, Zaki L, Zaman SB, Zamanian M, Zhang ZJ, Zhang Y, Ziapour A, Hay SI, Pigott DM. Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. PLoS neglected tropical diseases 2021.

Hutch MR, Liu M, Avillach P, , Luo Y, Bourgeois FT. National Trends in Disease Activity for COVID-19 Among Children in the US. Frontiers in pediatrics 2021.