The Boston Children's Hospital Computational Health Informatics Program (CHIP), founded in 1994, is a multidisciplinary applied research and education program. Our faculty advance the science of biomedical informatics for molecular characterization of the patient, gene discovery, medical decision making, diagnosis, therapeutic selection, care redesign, public health management, population health, and re-imagined clinical trials. Biomedical informatics has become a major theme and methodology for biomedical science, health care delivery, and population health, involving high-dimensional modeling and understanding of patients from the molecular to the population levels. The field is inherently interdisciplinary, drawing on traditional biomedical disciplines, the science and technology of computing, data science, biostatistics, epidemiology, decision theory, omics, implementation science, and health care policy and management. CHIP faculty are trained in medicine, data science, computer science, mathematics and epidemiology. Though CHIP has a robust pediatric research agenda, our contributions span across all ages. CHIP is a collaborating program with the Department of Biomedical Informatics at Harvard Medical School.

The Program’s innovations have transformed the landscape of big data in health care, the use of AI in clinical decision making, and the IT strategies of commercial enterprises. CHIP discoveries and inventions have been widely adopted by technology companies such as: Apple, Microsoft, Google, Facebook, and Amazon.

Leading projects include the SMART on FHIR “app store for health”, the cTAKES pipeline for computerized “reading” of clinical text, the HealthMap global surveillance system, the VaccineFinder tool to help the public locate COVID-19 vaccines, and the federated data sharing Genomic Information Commons.

CHIP software is reading millions of doctors’ notes across sites of care and surfacing key insights about adverse medication effects. CHIP research has strongly influenced public policy from vaccine recommendations to health IT provisions in the 21st Century Cures Act to paradigm shifts in data provisioning by CMS. CHIP’s biosurveillance computational platforms have found the earliest signals of Ebola outbreaks. On the basis of these advances, Health 2.0 voted Boston Children's Hospital the 10 Year Global Retrospective Top Influencer among all health care organizations.

Publications

Geisler BP, Zahabi L, Lang AE, Eastwood N, Tennant E, Lukic L, Sharon E, Chuang HH, Kang CB, Clayton-Johnson K, Aljaberi A, Yu H, Bui C, Le Mau T, Li WC, Teodorescu D, Hinske LC, Sun DL, Manian FA, Dunn AG. Repurposing existing medications for coronavirus disease 2019: protocol for a rapid and living systematic review. Systematic reviews 2021.

Börcsök J, Diossy M, Sztupinski Z, Prosz A, Tisza V, Spisak S, Rusz O, Stormoen DR, Pappot H, Csabai I, Brunak S, Mouw KW, Szallasi Z. Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 2021.

Geva A, Albert BD, Hamilton S, Manning MJ, Barrett MK, Mirchandani D, Harty M, Morgan EC, Kleinman ME, Mehta NM. eSIMPLER: A Dynamic, Electronic Health Record-Integrated Checklist for Clinical Decision Support During PICU Daily Rounds. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2021.

Li J, Tiwari A, Mirzakhani H, Wang AL, Kho AT, McGeachie MJ, Litonjua AA, Weiss ST, Tantisira KG. Circulating MicroRNA: Incident Asthma Prediction and Vitamin D Effect Modification. Journal of personalized medicine 2021.

Larsen RJ, Gagoski B, Morton SU, Ou Y, Vyas R, Litt J, Grant PE, Sutton BP. Quantification of magnetic resonance spectroscopy data using a combined reference: Application in typically developing infants. NMR in biomedicine 2021.